Using this Incase EO Travel Backpack is a breeze. First, pack your 17' laptop into the padded sleeve. For other items like chargers and cables, use the organizer pockets. If you're going on a longer trip, expand the main compartment to increase capacity. When carrying the backpack, adjust the shoulder straps for a comfortable fit. As for care, avoid using harsh chemicals when cleaning. Instead, use a soft, damp cloth to wipe off dirt. Store it in a dry place when not in use to maintain its weather - resistant properties. And remember, don't overload it beyond what the side compression straps can handle to keep the contents stable.